Zoloft is also used to treat the following:

• Premenstrual dysphoric disorder (PMDD), a condition marked by a depressed mood, anxiety or tension, emotional instability, and anger or irritability in the two weeks preceding menstruation.
• Obsessive-compulsive disorder (unwanted thoughts that won’t go away and an irresistible urge to keep repeating certain actions, such as hand-washing or counting).
• Panic disorder (unexpected attacks of overwhelming anxiety, accompanied by fear of their return).
• Social anxiety disorder (extreme shyness in social situations that interferes with an individual’s work and social life).
• Post-traumatic stress disorder (re-experiencing a dangerous or life-threatening event through intrusive thoughts, flashbacks, and intense psychological distress).

Zoloft belongs to a class of drugs called selective serotonin re-uptake inhibitors (SSRIs). Serotonin is one of the chemical messengers believed to govern moods. Ordinarily, it is quickly reabsorbed after its release at the junctures between nerves. Re-uptake inhibitors such as Zoloft slow this process, thereby boosting the levels of serotonin available in the brain.